ethyl 2-bromo-1,4-dimethyl-1H-imidazole-5-carboxylate → 2-(2,6-Dichloro-phenylethynyl)-3,5-dimethyl-3H-imidazole-4-carboxylic acid ethyl ester

HRID 488465Notes

Reaction equation

HRID 488465 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([Cl:8])[C:3]=1[C:9]#[CH:10].[CH2:11]([O:13][C:14]([C:16]1[N:17]([CH3:23])[C:18](Br)=[N:19][C:20]=1[CH3:21])=[O:15])[CH3:12]>>[CH2:11]([O:13][C:14]([C:16]1[N:17]([CH3:23])[C:18]([C:10]#[C:9][C:3]2[C:2]([Cl:1])=[CH:7][CH:6]=[CH:5][C:4]=2[Cl:8])=[N:19][C:20]=1[CH3:21])=[O:15])[CH3:12]

Participants

3

Reactant 2

HCID 13897513ethyl 2-bromo-1,4-dimethyl-1H-imidazole-5-carboxylateHCID 22271730Benzene, 1,3-dichloro-2-ethynyl-

Product 1

HCID 99457302-(2,6-Dichloro-phenylethynyl)-3,5-dimethyl-3H-imidazole-4-carboxylic acid ethyl ester

Procedure

The title compound, MS: m/e=197.4 (M+H+) was prepared in accordance with the general method of example 1b from 1,3-dichloro-2-ethynyl-benzene and 2-bromo-3,5-dimethyl-3H-imidazole-4-carboxylic acid ethyl ester.

Sources & evidence

ORD record
ord-b28d06cb6fec4d70a14d43b36095074e
Source dataset
uspto-grants-2005_12
Patent number
US06972299B2

Reaction notes

Loading…