HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Chlorobenzoic Acid → HCID 9951634, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Chlorobenzoic Acid | HCID 8374 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 4-(3,4-Dimethoxyphenethyl)aniline | HCID 14256024 | — |
| Catalyst | Copper | HCID 23978 | — |
| Catalyst | Cuprous chloride | HCID 62652 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 9951634 | HCID 9951634 | 33.3% |
Reaction Steps
The title compound was prepared from 4-[2-(3,4-dimethoxy-phenyl)-ethyl]phenylamine (9.25 g, 0.036 mol), 2-chlorobenzoic acid (5.2 g, 0.036 mol), anhydrous potassium carbonate (15.0 g, 0.11 mol), copper powder (0.45 g, 0.007 mol), and a catalytic amount of copper(I) chloride in dry DMF (75 mL) using the procedure described in Example 1, Step C, Method B. After crystallization with MeOH/H2O, 4.5 g (0.012 mol, 33%) of the desired product was obtained mp: 137-139° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06972287B1 |
| Source dataset | uspto-grants-2005_12 |
| ORD ID | ord-8105db5d3d104816b1b8f2a17ef8bc5b |
| Source note | uspto-grants-2005_12 |