Potassium Hydroxide → HCID 22269704, compound

HRID 488526Notes

Reaction equation

HRID 488526 reaction equation
C[O:2][C:3](=[O:29])[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[NH:10][C:11]1[CH:16]=[CH:15][C:14]([CH2:17][CH2:18][CH2:19][C:20]2[CH:25]=[CH:24][C:23]([NH:26][CH2:27][CH3:28])=[CH:22][CH:21]=2)=[CH:13][CH:12]=1.[OH-].[K+]>CCO>[CH2:27]([NH:26][C:23]1[CH:22]=[CH:21][C:20]([CH2:19][CH2:18][CH2:17][C:14]2[CH:15]=[CH:16][C:11]([NH:10][C:5]3[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=3[C:3]([OH:29])=[O:2])=[CH:12][CH:13]=2)=[CH:25][CH:24]=1)[CH3:28]

Participants

4

Reactant 2

HCID 14797Potassium HydroxideHCID 54551785HCID 54551785, compound

Product 1

HCID 22269704HCID 22269704, compoundYield 90%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

The title compound was prepared from 2-{4-[3-(4-ethylaminophenyl)-propyl]phenylamino}benzoic acid methyl ester (from Example 161), EtOH (10 mL), and 3 M-KOH solution (1.0 mL) using the procedure described in Example 162. This procedure yielded a yellow solid, 253 mg of the desired product (90% for 0.1 hydrate).

Sources & evidence

ORD record
ord-ce58d0889dd64f00a3dc78d654439773
Source dataset
uspto-grants-2005_12
Patent number
US06972287B1

Reaction notes

Loading…