反应详情

温度

95 °C

The reaction was carried out as described in Reference Example 1 and the reaction mixture obtained after completion of the reaction was neutralized at pH 6.5 by adding an 18% aqueous sodium hydroxide solution while maintaining the temperature at 40–50° C. Next, the temperature of the reaction mixture thus neutralized was raised to 95° C. to dissolve the generated BPTMC adduct crystals, after which the resulting water phase was removed by separation, and the temperature of the oil phase obtained was rapidly lowered to 40° C. with a temperature gradient of about 20° C./hour to crystallize the BPTMC-phenol adduct, and the crystals of the BPTMC-phenol adduct were obtained by centrifugal filtration.

1. customthe reaction mixture obtained after completion of the reaction
2. temperaturewhile maintaining the temperature at 40–50° C
3. customafter which the resulting water phase was removed by separation
4. customthe temperature of the oil phase obtained
5. customwas rapidly lowered to 40° C. with a temperature gradient of about 20° C./hour
6. customto crystallize the BPTMC-phenol adduct