Sodium Hydroxide → HCID 178491592, compound

Participants

Reaction Conditions

Reaction Steps

Compound (12) (1.43 g; 2 mmole) is dissolved in dioxane (10 ml). The solution is cooled to 0° C., and 1 M aqueous NaOH (8.66 ml) is added drop-wise in 5 aliquots over 2.5 hours. After an additional 2 hours at room temperature, the pH is adjusted to 5 by drop-wise addition of 2M HKSO4. Precipitated salts are filtered off, washed with dioxane, then the combined filtrates are dried in vacuo. The residue (13) is co-evaporated with ethanol and methanol/CH2Cl2, then purified by silica gel chromatography.

Provenance & Evidence