HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Hydroxyisobutyric acid → 2-Methyl-2-(5-(trifluoromethyl)pyridin-2-yloxy)propanoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Hydroxyisobutyric acid | HCID 11671 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 2-Chloro-4-trifluoromethylpyridine 2-chloro-5-trifluoromethylpyridine | HCID 22270567 | — |
| Product | 2-Methyl-2-(5-(trifluoromethyl)pyridin-2-yloxy)propanoic acid | HCID 16098342 | — |
Reaction Steps
The title compound was prepared following the procedure described in Reference Example 91, Step A with 1.5 extra equivalent of sodium hydride substituting lithium lactate with hydroxyisobutyric acid and 2-chloro-4-trifluoromethylpyridine 2-chloro-5-trifluoromethylpyridine. 1H NMR (500 MHz, CD3OD): δ 8.38 (br, 1H), 7.94 (dd, 1H), 6.93 (d, 1H), 1.69 (s, 6H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06972295B2 |
| Source dataset | uspto-grants-2005_12 |
| ORD ID | ord-1918ce1430c147d0a8409f52921e7cbb |
| Source note | uspto-grants-2005_12 |