2-(6-Methyl-3-pyridyloxy)-2-methylpropionic Acid → N-[2,3-Bis(4-Chlorophenyl)-1-methylpropyl]-2-(6-methyl-3-pyridyloxy)-2-methylpropanamide

HRID 488630Notes

Reaction equation

HRID 488630 reaction equation
[CH3:1][C:2]1[N:7]=[CH:6][C:5]([O:8][C:9]([CH3:14])([CH3:13])[C:10]([OH:12])=O)=[CH:4][CH:3]=1.Cl.[Cl:16][C:17]1[CH:22]=[CH:21][C:20]([CH:23]([CH2:27][C:28]2[CH:33]=[CH:32][C:31]([Cl:34])=[CH:30][CH:29]=2)[CH:24]([NH2:26])[CH3:25])=[CH:19][CH:18]=1>>[Cl:16][C:17]1[CH:22]=[CH:21][C:20]([CH:23]([CH2:27][C:28]2[CH:29]=[CH:30][C:31]([Cl:34])=[CH:32][CH:33]=2)[CH:24]([NH:26][C:10](=[O:12])[C:9]([O:8][C:5]2[CH:6]=[N:7][C:2]([CH3:1])=[CH:3][CH:4]=2)([CH3:14])[CH3:13])[CH3:25])=[CH:19][CH:18]=1

Participants

3

Reactant 2

HCID 222704032-(6-Methyl-3-pyridyloxy)-2-methylpropionic AcidHCID 222704272,3-Bis(4-chlorophenyl)-1-methylpropylamine hydrochloride

Product 1

HCID 22270440N-[2,3-Bis(4-Chlorophenyl)-1-methylpropyl]-2-(6-methyl-3-pyridyloxy)-2-methylpropanamide

Procedure

The title compound was prepared by reacting 2-(6-methyl-3-pyridyloxy)-2-methylpropionic acid (Step B, 75 mg, 0.63 mmol) with 2-amino-3,4-bis(4-chlorophenyl)butane hydrochloride salt (Diastereomer α, Reference Example 1) (0.23 g, 0.63 mmol) following the procedure described in Example 62-63. LC-MS: m/e 471 (M+H)+ (3.1 min).

Workup

  1. customm/e 471 (M+H)+ (3.1 min)

Sources & evidence

ORD record
ord-a8e3acd382f343ba83c41038fd0b6b68
Source dataset
uspto-grants-2005_12
Patent number
US06972295B2

Reaction notes

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