(2S)-2-[(5-{[2-(acetylamino)-3-(4-{2-[(benzhydryloxy)carbonyl][tert-butoxy(oxo)acetyl]anilino}-3-ethylphenyl)propanoyl]amino}pentanoyl)amino]-3-(4-tert-butoxyphenyl)propanoic acid → N-(5-{[3-(4-[(carboxycarbonyl)(2-carboxyphenyl)amino]-1-naphthyl)-N-(methoxycarbonyl)alanyl]amino}pentanoyl)-L-methionine

Participants

Reaction Steps

The titled compound was prepared according to the procedure described in Example 1L, substituting the ester from Example 1K with the ester from Example 7L. MS (ESI+) m/e 711 (M+H)+, 1H NMR (300 MHz, DMSO-d6) 1.23-1.64 (m, 4H), 1.71-2.22 (m, 4H), 2.03 (s, 3H), 2.35-2.56 (m, 2H), 2.97-3.59 (m, 7H), 4.00-4.67 (m, 2H), 6.70-7.80 (m, 6H), 7.86 (d, J=6.3 Hz, 1H), 7.92-8.34 (m, 4H), 8.43 (d, J=9.3 Hz, 1H).

Provenance & Evidence