HCID 86585329, compound → HCID 10168788, compound

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A mixture of methyl 2-(4-{[4-{{2-[(benzhydryloxy)carbonyl]phenyl}[(benzyloxy)(oxo)acetyl]amino}-N-(methoxycarbonyl)-L-phenylalanyl]amino}butoxy)-6-hydroxy-4-methoxybenzoate and 10% Pd—C (0.1 g) in methanol (25 mL) was stirred under an atmosphere of hydrogen at ambient temperature for 16 hours. The mixture was filtered through celite and the filtrate concentrated under reduced pressure to provide the titled compound. MS (ESI(+)) m/e 682 (M+H)+; 1H NMR (500 MHz, DMSO-d6) 10.66, 10.67 (s, s, 1H), 8.03-7.96 (m, 1H), 7.90-7.83 (m, 1H), 7.63-7.15 (m, 8H), 6.07-6.05 (m, 2H), 4.18-4.10 (m, 1H), 3.95-3.89 (m, 2H), 3.73 (s, 3H), 3.43 (s, 3H), 3.15-3.02 (m, 2H), 2.95-2.86 (m, 1H), 2.78-2.68 (m, 1H), 1.68-1.56 (m, 2H), 1.54-1.47 (m, 2H).

Provenance & Evidence