HCID 86585331, compound → HCID 86585330, compound

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Reaction Steps

A solution of methyl 3-(4-{[4-{{2-[(benzhydryloxy)carbonyl]phenyl}[(benzyloxy)(oxo)acetyl]amino}-N-(methoxycarbonyl)-L-phenylalanyl]amino}butoxy)-5-hydroxy-1,1′-biphenyl-4-carboxylate (120 mg, 0.12 mM) in methanol (25 mL) was stirred for 16 hours over 10% Pd/C under an atmosphere of H2. The mixture was filtered, concentrated under reduced pressure and purified by preparative HPLC to give the desired product. MS (ESI(+)) m/e 728 (M+H)+; 1H NMR (300 MHz, DMSO-d6) δ 10.15 (bs, 1H), 8.13-8.06 (m, 1H), 7.99-7.06 (m, 1H), 7.73-7.12 (m, 13H), 6.99-6.89 (m, 2H), 6.74-6.71 (m, 2H), 4.13-4.08 (m, 1H), 4.06-4.02 (m, 2H), 3.75 (s, 3H), 3.43 and 3.42 (2s, 3H total), 3.12-3.06 (m, 2H), 2.89-2.83 (m, 1H), 2.76-2.65 (m, 1H), 1.64-1.58 (m, 2H), 1.53-1.47 (m, 2H).

Provenance & Evidence