5,6-Dimethylbenzimidazole → 2-[1-(5,6-Dimethyl-benzoimidazol-1-ylmethyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(indan-1-yl)-acetamide

HRID 48869Notes

Reaction equation

HRID 48869 reaction equation
O[CH2:2][CH:3]1[C:12]2[C:7](=[CH:8][C:9]([O:15][CH3:16])=[C:10]([O:13][CH3:14])[CH:11]=2)[CH2:6][CH2:5][N:4]1[CH2:17][C:18]([NH:20][CH:21]1[C:29]2[C:24](=[CH:25][CH:26]=[CH:27][CH:28]=2)[CH2:23][CH2:22]1)=[O:19].[CH3:30][C:31]1[C:39]([CH3:40])=[CH:38][C:34]2[N:35]=[CH:36][NH:37][C:33]=2[CH:32]=1>>[CH3:30][C:31]1[C:39]([CH3:40])=[CH:38][C:34]2[N:35]([CH2:2][CH:3]3[C:12]4[C:7](=[CH:8][C:9]([O:15][CH3:16])=[C:10]([O:13][CH3:14])[CH:11]=4)[CH2:6][CH2:5][N:4]3[CH2:17][C:18]([NH:20][CH:21]3[C:29]4[C:24](=[CH:25][CH:26]=[CH:27][CH:28]=4)[CH2:23][CH2:22]3)=[O:19])[CH:36]=[N:37][C:33]=2[CH:32]=1

Participants

3

Reactant 2

HCID 6755,6-DimethylbenzimidazoleHCID 227427252-(1-Hydroxymethyl-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-N-(indan-1-yl)-acetamide

Product 1

HCID 227427702-[1-(5,6-Dimethyl-benzoimidazol-1-ylmethyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(indan-1-yl)-acetamide

Procedure

prepared by reaction of 2-(1-Hydroxymethyl-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-N-(indan-1-yl)-acetamide with 5,6-dimethylbenzimidazole

Sources & evidence

ORD record
ord-4104f329d85a4c98994e9afb5f8c7e13
Source dataset
uspto-grants-2004_03
Patent number
US06703392B2

Reaction notes

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