反应详情

温度

70 °C

A mixture of 2 (1 mmol), 3-aminoheptane (1.2 mmol), Pd2(DBA)3 (0.02 mmol, 4 mol % Pd, 18 mg), BINP (0.04 mmol, 25 mg), NaOtBu (1.4 mmol, 134 mg), and toluene (0.11 M with 3-bromopyridine, 9 ml) is heated to 70° C. under nitrogen until 2 is consumed. The reaction is then cooled to room temperature, and taken up in 10 ml diethyl ether, washed 3 times with 10 ml saturated brine, dried over MgSO4, and condensed in vacuo. The crude product is purified by flash chromatography to afford 3.

1. customis consumed
2. temperatureThe reaction is then cooled to room temperature
3. washwashed 3 times with 10 ml saturated brine
4. dry with materialdried over MgSO4, and condensed in vacuo
5. customThe crude product is purified by flash chromatography
6. customto afford 3