反应详情

To 2-(4-chloro-2-hydroxymethyl-phenoxy)-1-[4-(4-fluoro-benzyl)-(2R,5S)-2,5-dimethyl-piperazin-1-yl]-ethanone (0.55 g, 1.3 mmol) in methylene chloride (6 ml) was added thionyl chloride (0.26 ml, 3.58 mmol). The reaction was heated to reflux for 2 hours. After cooling the reaction was quenched by the addition of water. The organic layer was washed with saturated sodium bicarbonate followed by saturated aqueous sodium chloride. The organic layer was then concentrated to afford the title compound as a yellow oil (0.52 g).

1. temperatureThe reaction was heated
2. temperatureto reflux for 2 hours
3. temperatureAfter cooling the reaction
4. customwas quenched by the addition of water
5. washThe organic layer was washed with saturated sodium bicarbonate
6. concentrationThe organic layer was then concentrated