反应详情

To a solution of (5-chloro-2-methoxy-phenyl)-acetonitrile (17.2 g, 96.3 mmol) in ethanol (200 mL) and water (20 mL) was added potassium hydroxide (27 g, 481 mmol). The reaction was heated to reflux for 12 hours, cooled and the ethanol was removed by concentrating in vacuo. The remaining solution was acidified with aqueous hydrochloric acid (3 M) and extracted with diethyl ether. The organic layer was dried over magnesium sulfate and concentrated in vacuo to give the title compound (15.6 g).

1. temperatureThe reaction was heated
2. temperatureto reflux for 12 hours
3. temperaturecooled
4. customthe ethanol was removed
5. concentrationby concentrating in vacuo
6. extractionextracted with diethyl ether
7. dry with materialThe organic layer was dried over magnesium sulfate
8. concentrationconcentrated in vacuo