HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → HCID 22268230, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Benzylacetylene | HCID 575753 | — |
| Reactant | 4-(7-bromo-3-oxo-2H-6-azaisoquinolin-2-ylmethyl)benzenesulfonamide | HCID 22268239 | — |
| Catalyst | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| Catalyst | HCID 178418397 | HCID 178418397 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 22268230 | HCID 22268230 | — |
Reaction Steps
The coupling of 4-(7-bromo-3-oxo-2H-6-azaisoquinolin-2-ylmethyl)benzenesulfonamide (0.71 g, 1.81 mmol) with 3-phenyl-1-propyne (0.56 mL, 4.51 mmol) using triethylamine (0.50 mL, 3.61 mmol), CuI (0.025 g, 0.13 mmol), and Pd(Ph3P)4 (0.084 g, 0.07 mmol) in dimethylformamide is carried out as described in Example 1, Step (2). Purification is carried out on a silica gel column eluted with hexanes/ethyl acetate 3:1 to give the desired product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06974822B2 |
| Source dataset | uspto-grants-2005_12 |
| ORD ID | ord-90327ee5600647819bc99e48d4c9a263 |
| Source note | uspto-grants-2005_12 |