Hydrochloric Acid → HCID 22267251, compound

Participants

Reaction Steps

A solution of 2-(7-chloro-6-methoxy-2-oxo-4-phenyl-2H-chromen-3-yl)-N-[4-chloro-2-(trifluoromethyl)phenyl]acetamide (Example 178) (3.20 g) in methylene chloride (10 ml) was combined with a 1 M solution of boron tribromide/methylene chloride (31.6 ml, 13.6 mmol), and stirred at room temperature for 3 days. The reaction solution was poured into an ice water, to which concentrated hydrochloric acid was then added. The precipitate was filtered and washed with isopropanol followed by ether to obtain the title compound as a colorless crystal (2.05 g, 64%). An aliquot was recrystallized from THF-isopropyl ether to measure a melting point. Melting point: 246-247° C.

Provenance & Evidence