Hydrochloric Acid → HCID 22267292, compound

Participants

Reaction Steps

A suspension of NaBH4 (30 mg) in DME (2 ml) was combined with 2-(2,8-dioxo-4-phenyl-2,6,7,8-tetrahydrocyclopenta[g]chromen-3-yl)-N-[4-fluoro-2-(trifluoromethyl)phenyl]-acetamide (Example 88) (170 mg) with cooling in ice, and further combined with methanol, and stirred at room temperature for 10 minutes. The reaction solution was poured into diluted hydrochloric acid, which was then extracted with ethyl acetate. The extract was washed with water, and then dried over magnesium sulfate, and concentrated under reduced pressure to obtain the title compound as a colorless crystal (110 mg, yield: 65%). An aliquot was recrystallized from ethyl acetate to measure a melting point. Melting point: 217-218° C.

Provenance & Evidence