HCID 22267292, compound → HCID 22267286, compound

Participants

Reaction Steps

A solution of N-[4-fluoro-2-(trifluoromethyl)phenyl]-2-(8-hydroxy-2-oxo-4-phenyl-2,6,7,8-tetrahydrocyclopenta[g]chromen-3-yl)acetamide (Example 214) (250 mg) in toluene (50 ml) was combined with p-TsOH monohydrate (300 mg), and heated under reflux for 30 minutes. After the reaction solution was concentrated, the resultant residue was purified by a silica gel column chromatography (eluent: hexane-ethyl acetate=3:1) to obtain the title compound as a colorless crystal (200 mg, yield: 74%). An aliquot was recrystallized from THF to measure a melting point. Melting point: 217-218° C.

Provenance & Evidence