Methyl Acrylate → HCID 58600634, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 2-(6-bromo-7-methyl-2-oxo-4-phenyl-2H-chromen-3-yl)-N-[4-fluoro-2-(trifluoromethyl)phenyl]acetamide (Example 177) (500 mg) in DMF (5 mL) was combined with methyl acrylate (0.14 mL), Et3N (0.21 mL), Pd(OAc)2 (5 mg) and triphenylphosphine (10 mg) under argon atmosphere, and stirred with heating at 120° C. for 10 hours. The reaction solution was combined with water and extracted with ethyl acetate. The extract was washed with diluted hydrochloric acid followed by an aqueous solution of NaHCO3 and water, and then dried over magnesium sulfate, and concentrated under reduced pressure to obtain the title compound as a colorless crystal (360 mg, yield: 72%). An aliquot was recrystallized from ethyl acetate to measure a melting point. Melting point: 233-236° C.

Provenance & Evidence