Hydrochloric Acid → HCID 10231798, compound

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Reaction Steps

A solution of ethyl (2E)-3-[3-[7-chloro-3-(2-[[4-chloro-2-(trifluoromethyl)phenyl]amino]-2-oxoethyl)-6-methyl-2-oxo-2H-chromen-4-yl]phenyl]-2-propenoate (200 mg) in a mixture of ethanol (5 ml) and THF (2 ml) was combined with a 1 N aqueous solution of sodium hydroxide (3 ml), and stirred at room temperature for 4 hours. After 1 N hydrochloric acid (10 ml) was added, the mixture was extracted with ethyl acetate. The extract was washed with water, dried over magnesium sulfate, and then concentrated. The resultant crude crystal was recrystallized from THF-ethyl acetate to obtain the title compound as a colorless crystal (137 mg, yield: 70%). Melting point: 191-194° C.

Provenance & Evidence