HCID 22267250, compound → HCID 22267242, compound

Participants

Reaction Steps

A mixture solution of 2-[7-chloro-6-methyl-4-(3-nitrophenyl)-2-oxo-2H-chromen-3-yl]-N-[4-chloro-2-(trifluoromethyl)phenyl]acetamide (300 mg) in ethanol (2 ml) and THF (5 ml) was combined with Raney-nickel (50 mg), and stirred under hydrogen atmosphere at room temperature for 5 hours. After catalyst was filtered off, the reaction solution was concentrated. The resultant residue was purified by a silica gel chromatography (eluent: hexane-ethyl acetate=2:1), and further recrystallized from THF-ethyl acetate to obtain the title compound as a colorless crystal (166 mg, yield: 59%). Melting point: 206-207° C.

Provenance & Evidence