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Methanol → 5-TFA-ap-ddU
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methanol | HCID 887 | — |
| 反応物 | 2,2,2-trifluoro-N-(prop-2-yn-1-yl)acetamide | HCID 11094805 | — |
| 反応物 | Iodouridine | HCID 66601875 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 5-TFA-ap-ddU | HCID 14768541 | — |
反応手順
Iodouridine 21 was coupled for 3 hours to N-propargyltrifluoroacetamide following the general method given in Example 5C. Chromatography with a 0-5% methanol in dichloromethane gradient afforded material which was homogeneous by TLC, but which was difficult to dry. After co-evaporating the chromatographed product several times with chloroform and vacuum-drying, 536.5 mg of alkynylamino nucleoside 22 was obtained as a white foam. This material was homogeneous by TLC and was pure by NMR except for a small amount (39 mole%; corrected yield 66%) of chloroform.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05242796 |
| 出典データセット | uspto-grants-1993_09 |
| ORD ID | ord-f862215dba7846cf8cae5bec600dc198 |
| 出典メモ | uspto-grants-1993_09 |