Aniline → HCID 750059, compound

Participants

Reaction Steps

A solution of 20 mg trifluoromethanesulfonic acid 3-amino-2-carbamoyl-thieno[2,3-b]pyridin-4-yl ester and 27 microL aniline in 1 mL of THF was heated at 55° C. overnight under Ar. The reaction was applied to a 2 mm silica gel prep plate that was developed twice in 5% MeOH—CH2Cl2. The band was eluted with 50% MeOH—CH2Cl2 to get 18 mg. This was dissolved in 5% MeOH—CH2Cl2, filtered, concentrated, and dried in vacuo at 60° C. overnight to provide 10.5 mg of the title compound as a yellow-green solid.

Provenance & Evidence