HCID 10407249, compound → HCID 10378795, compound

Participants

Reaction Steps

A solution of 18 mg 4-(3-amino-2-carbamoyl-thieno[2,3-b]pyridin-4-yl)-piperazine-1-carboxylic acid tert-butyl ester in 1 mL CH2Cl2+1 mL trifluoroacetic acid was stirred with a drying tube for 4 h at room temperature. The reaction was concentrated in vacuo and developed prep plate in 25% MeOH—CH2Cl2−2% NH4OH and the band was eluted with 50% MeOH—CH2Cl2 to get an oil that was re-dissolved 10% MeOH—CH2Cl2, filtered, concentrated, and dried in vacuo at 60° C. to provide 4.6 mg of the product as a yellow solid.

Provenance & Evidence