4-Ethylbenzaldehyde → HCID 10303660, compound

Participants

Reaction Steps

The compound 1.2 (Z=—C(O)—, R2=2-(isopropylaminocarbonyl)amino-5-(trifluoromethyl)phenyl, all other R=H; cf. procedure (65a); 0.93 g, 2.67 mmol) and (2S, 3S)-11.5 (l=m=0, PGN=CbzHN, R=propynyl, all other R=H; cf. procedure (68a); 1.0 g, 2.76 mmol) were combined in procedure (1c). A portion (52 mg, 0.11 mmol) of the resultant product was combined with 4-ethylbenzaldehyde (0.015 mL, 0.11 mmol) and taken through procedure (1d). The crude product was purified by RP-HPLC to afford the title compound (1S, 2S)-1.5 (l=m=0, R1=4-ethylphenyl, R3=—CH(OH)n-propyl, Z=—C(O)—, R2=2-(isopropylaminocarbonyl)amino-5-(trifluoromethyl)phenyl, all other R=H; 20 mg). Exact MS calcd for C29H41F3N5O4, the formula for (M+H)+=580.3111. Found: 580.3131.

Provenance & Evidence