Hydrochloric Acid → HCID 22268688, compound

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A mixture of 2-[[3-(2-amino-1,2-dioxoethyl)-2-methyl-1-[2-(5-bromothiophen-2-yl)benzyl]-1,6,7,8-tetrahydrocyclopent[g]indol-4-yl]oxy]acetic acid methyl ester (50 mg, 0.086 mmol) in dioxane (5 mL) was warmed until a clear solution was obtained. This solution was treated with 1M lithium hydroxide solution (1 mL) at room temperature for 90 min. The pH was adjusted to ˜3 with hydrochloric acid. The mixture was diluted with water and stirred for 15 min. The resulting precipitate was collected via vacuum filtration to provide 25 mg (51%) of the title compound as a green solid. TOS MS ES+ exact mass calculated for C27H24BrN2O5S (p+1): m/z=567.0589. Found: 567.0603.

Provenance & Evidence