Cesium carbonate → 4-(7-bromo-1-oxo-1H-6-azaisoquinolin-2-ylmethyl)benzenesulfonamide

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Reaction Steps

The alkylation of 7-bromo-1-hydroxy-6-azaisoquinoline (1.00 g, 4.40 mmol) using 4-bromomethyl-benzene sulfonamide (1.67 g, 6.69 mmol) and cesium carbonate (2.18 g, 6.69 mmol) in dimethyl-formamide is carried out as previously described in Example 1, Step (1). Purification on a silica gel column eluted with hexanes/ethyl acetate 3:1, followed by trituration with hexanes/ethyl acetate 4:1 will afford the desired product. Step (2): 4-[1-oxo-7-(3-phenyl-prop-1-ynyl)-1H-6-azaisoquinolin-2-ylmethyl]benzenesulfonamide

Provenance & Evidence