Cesium carbonate → HCID 22265327, compound

Participants

Reaction Steps

The alkylation of 7-bromo-1-hydroxy-3,8-diazaisoquinoline (1.00 g, 4.46 mmol) using 3-Chlorobenzyl bromide (1.37 g, 6.69 mmol) and cesium carbonate (2.18 g, 6.69 mmol) in dimethyl-formamide is carried out as previously described in Example 1, Step (1). Trituration with hexanes/ethyl acetate 10:1 will afford the desired product. Step 2): 2-(3-chlorobenzyl)-7-(3-phenylprop-1-ynyl)-2H-3,8-diazaisoquinolin-1-one

Provenance & Evidence