Methyl iodide → Trimethyl(4-hydroxy-3-methoxy-5-methylbenzyl)ammonium iodide

Participants

Reaction Steps

To a dioxane solution (600 ml) of dimethyl(4-hydroxy-3-methoxy-5-methylbenzyl)amine (98 g, 0.50 mol) was added methyl iodide (69 ml, 1.11 mol) and the resulting mixture was refluxed for 2 h. The solid formed was filtered and washed with dioxane to yield 165 g (98%) of the trimethyl(4-hydroxy-3-methoxy-5-methylbenzyl)ammonium iodide salt.

Provenance & Evidence