Pyrrolidine → HCID 60054651, compound

Participants

Reaction Steps

A mixture of Example 11 (8.9 g, 16.7 mmol), TEA (3.8 ml) and pyrrolidine (2.2 ml) in THF (270 ml) was refluxed for 2 h 30 min. The mixture was concentrated in vacuo and taken into DCM, then washed with water. The organic layer was dried over MgSO4 and concentrated. The resulting solid was chromatographed over silica gel (eluent: DCM/MeOH 95/5) to yield the above-titled compound (9.3 g) as a white solid (mp=200° C.). 1H NMR (DMSO-d6): 9.32 (1H, br s), 7.84 (2H, d, J=8.2 Hz), 7.60 (1H, m), 7.25-7.45 (7H, m), 6.74 (2H, d, J=1.9 Hz), 3.65-3.9 (3H, m), 3-3.3 (4H, m).

Provenance & Evidence