Thionyl Chloride → HCID 22266508, compound

HRID 489303Notes

Reaction equation

HRID 489303 reaction equation
[CH2:1]([N:5]1[C:10](=[O:11])[C:9]([C:12](O)=[O:13])=[CH:8][C:7]2[CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][C:6]1=2)[CH2:2][CH2:3][CH3:4].S(Cl)([Cl:23])=O>C1(C)C=CC=CC=1>[CH2:1]([N:5]1[C:10](=[O:11])[C:9]([C:12]([Cl:23])=[O:13])=[CH:8][C:7]2[CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][C:6]1=2)[CH2:2][CH2:3][CH3:4]

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 22266520HCID 22266520, compound

Product 1

HCID 22266508HCID 22266508, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

1-Butyl-2-oxo-1,2,5,6,7,8,9,10-octahydrocycloocta[b]pyridine-3-carboxylic acid (B-01) (416 mg, 1.50 mmol) was dissolved in toluene (15 ml), and to the reaction mixture was added thionyl chloride (328 μL, 4.50 mmol), and the reaction mixture was reacted at 65° C. for 20 min. The reaction mixture was evaporated under reduced pressure to give 1-butyl-2-oxo-1,2,5,6,7,8,9,10-octahydrocycloocta[b]pyridine-3-carbonyl chloride (B-02).

Workup

  1. customthe reaction mixture was reacted at 65° C. for 20 min
  2. customThe reaction mixture was evaporated under reduced pressure

Sources & evidence

ORD record
ord-9c83bc62ceac45d08591b25afed29068
Source dataset
uspto-grants-2005_12
Patent number
US06977266B2

Reaction notes

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