2-Chlorobenzaldehyde → HCID 178469200, compound

Participants

Reaction Steps

A solution of 2-chlorobenzaldehyde (1.7 g), 3-aminopyrazole (1.0 g) and ethyl acetoacetate (1.6 g) in acetonitrile (20 mL) was heated under reflux overnight. The reaction mixture was cooled to room temperature and the solvent was evaporated under reduced pressure to give an oil. The oil was purified by silica gel column chromatography (eluent:hexane-ethyl acetate (8:2)) to give the title compound (850 mg) as colorless crystals.

Provenance & Evidence