Hydrazine → HCID 178429573, compound

HRID 489313Notes

Reaction equation

HRID 489313 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH:8]1[C:13]([C:14]([N:16](C)C)=[O:15])=[C:12]([CH3:19])[NH:11][C:10]2=[N:20][NH:21][CH:22]=[C:9]12.[NH2:23]N>C(#N)C>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH:8]1[C:13]([C:14]([NH:16][NH2:23])=[O:15])=[C:12]([CH3:19])[NH:11][C:10]2=[N:20][NH:21][CH:22]=[C:9]12

Participants

4

Reactant 2

HCID 9321HydrazineHCID 178429308HCID 178429308, compound

Product 1

HCID 178429573HCID 178429573, compoundYield 78.2%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

To a solution of 4-(2-chlorophenyl)-4,7-dihydro-5-dimethylaminocarbonyl-6-methyl-2H-pyrazolo[3,4-b]pyridine (200 mg) in acetonitrile (200 mL) was added hydrazine (200 mg) and the mixture was heated under reflux overnight. The reaction mixture was cooled to room temperature, and the precipitated crystals were collected by filtration and washed with ethyl acetate to give the title compound as colorless crystals (150 mg).

Workup

  1. temperaturethe mixture was heated
  2. temperatureunder reflux overnight
  3. filtrationthe precipitated crystals were collected by filtration
  4. washwashed with ethyl acetate

Sources & evidence

ORD record
ord-f495c27c6c504f7096cf242fe1c0035e
Source dataset
uspto-grants-2005_12
Patent number
US06977262B2

Reaction notes

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