Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Potassium Carbonate → 4-[4-(Diethoxy-phosphorylmethyl)-piperazin-1-ylmethyl]-benzoic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | Phosphonic acid, P-(chloromethyl)-, diethyl ester | HCID 76633 | — |
| 반응물 | 4-(1-Piperazinylmethyl)benzoic acid | HCID 17606055 | — |
| 용매 | Ethanol | HCID 702 | — |
| 용매 | Sodium chloride; water | HCID 57417360 | — |
| 생성물 | 4-[4-(Diethoxy-phosphorylmethyl)-piperazin-1-ylmethyl]-benzoic acid | HCID 20634549 | — |
반응 단계
To a solution of 4-Piperazin-1-ylmethyl-benzoic acid (4c) and chloromethyl-phosphonic acid diethyl ester (4d) in ethanol was added potassium carbonate. The resulting reaction mixture was refluxed, then cooled to room temperature, diluted with brine, acidified to pH˜4, and extracted with EtOAc until the aqueous layer showed little or no evidence of product by HPLC. The combined organics were dried over MgSO4 and concentrated on rotary evaporator. The desired product was purified by silica gel flash chromatography.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06706699B2 |
| 출처 데이터셋 | uspto-grants-2004_03 |
| ORD ID | ord-ed6d76fa55dd42c390a02af3e2ddcee4 |
| 출처 메모 | uspto-grants-2004_03 |