2,1,3-Benzoxadiazole-4-carbaldehyde → HCID 178473781, compound

HRID 489444Notes

Reaction equation

HRID 489444 reaction equation
[N:1]1[O:2][N:3]=[C:4]2[C:9]([CH:10]=O)=[CH:8][CH:7]=[CH:6][C:5]=12.[NH2:12][C:13]1[CH:17]=[CH:16][NH:15][N:14]=1.[C:18]([N:21]1[CH2:26][CH2:25][CH:24]([C:27](=O)[CH2:28][C:29]#[N:30])[CH2:23][CH2:22]1)(=[O:20])[CH3:19]>C(#N)C>[C:18]([N:21]1[CH2:22][CH2:23][CH:24]([C:27]2[NH:12][C:13]3=[N:14][NH:15][CH:16]=[C:17]3[CH:10]([C:9]3[C:4]4[C:5](=[N:1][O:2][N:3]=4)[CH:6]=[CH:7][CH:8]=3)[C:28]=2[C:29]#[N:30])[CH2:25][CH2:26]1)(=[O:20])[CH3:19]

Participants

5

Reactant 3

HCID 102908732,1,3-Benzoxadiazole-4-carbaldehydeHCID 22265419HCID 22265419, compoundHCID 178418806HCID 178418806, compound

Product 1

HCID 178473781HCID 178473781, compoundYield 62.1%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

To a solution of ethyl isonipecotate (8.0 g) in THF (100 mL) was added triethylamine (5.7 g), dimethylaminopyridine (0.6 g) and acetyl chloride (4.4 g) at 0° C. and the mixture was stirred for an hour. The mixture was extracted with ethyl acetate and the solvent was evaporated under reduced pressure to give ethyl 1-acetylpiperidine-4-carboxylate (10 g) as a colorless oil. To a solution of acetonitrile (2.5 g) in THF (300 mL) was added n-BuLi (57 mmol) at −78° C. Further, ethyl 1-acetylpiperidine-4-carboxylate (10 g) was added and the mixture was stirred for an hour. After acidification with hydrochloric acid, the mixture was extracted with ethyl acetate. The solvent was evaporated under reduced pressure and the residue was purified by silica gel column chromatography (eluent:hexane-ethyl acetate (10:1)) to give 1-(1-acetylpiperidin-4-yl)-2-cyanoethan-1-one (7.5 g) as a colorless oil. A solution of 2,1,3-benzoxadiazole-4-aldehyde (0.3 g), 3-aminopyrazole (0.17 g) and 1-(1-acetylpiperidin-4-yl)-2-cyanoethan-1-one (0.4 g) in acetonitrile (10 mL) was heated under reflux overnight. The reaction mixture was cooled to room temperature, and the precipitated crystals were collected by filtration to give the title compound (0.49 g) as yellow crystals.

Workup

  1. temperatureunder reflux overnight
  2. filtrationthe precipitated crystals were collected by filtration

Sources & evidence

ORD record
ord-0839af5f99cd49a18fbb1528cd7666f0
Source dataset
uspto-grants-2005_12
Patent number
US06977262B2

Reaction notes

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