HCID 178454401, compound → HCID 178479169, compound

HRID 489450Notes

Reaction equation

HRID 489450 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH:8]1[C:13]([C:14]#[N:15])=[C:12]([CH:16]2[CH2:21][CH2:20][N:19](OC(C)(C)C)[C:18](=C=O)[CH2:17]2)[NH:11][C:10]2=[N:29][NH:30][CH:31]=[C:9]12>O1CCOCC1.Cl>[ClH:1].[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH:8]1[C:13]([C:14]#[N:15])=[C:12]([CH:16]2[CH2:17][CH2:18][NH:19][CH2:20][CH2:21]2)[NH:11][C:10]2=[N:29][NH:30][CH:31]=[C:9]12

Participants

3

Reactant 1

HCID 178454401HCID 178454401, compound

Product 1

HCID 178479169HCID 178479169, compoundYield 139.7%

Reagents, catalysts & solvents 1

HCID 204431481,4-Dioxane hydrochlorideSolvent

Procedure

4-(2-Chlorophenyl)-5-cyano-4,7-dihydro-6-(1-t-butoxy-carbonylpiperidin-4-yl)-2H-pyrazolo[3,4-b]pyridine (2.0 g) was added to 4N-HCl dioxane solution (20 mL) at 0° C. and the mixture was stirred for an hour. The solvent was evaporated under reduced pressure and the residue was washed by ethanol, and the precipitated crystals were collected by filtration to give the title compound (1.2 g) as yellow crystals.

Workup

  1. customThe solvent was evaporated under reduced pressure
  2. washthe residue was washed by ethanol
  3. filtrationthe precipitated crystals were collected by filtration

Sources & evidence

ORD record
ord-45a89db5596b4ef49c1b5e7f839db77e
Source dataset
uspto-grants-2005_12
Patent number
US06977262B2

Reaction notes

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