1-Methylhomopiperazine → 4-(2-chlorophenyl)-6-[(4-methyl-1,4-diazepan-1-yl)methyl]-2,4-dihydro-1H-pyrazolo[3,4-b]pyridine-5-carbonitrile;dihydrochloride

HRID 489454Notes

Reaction equation

HRID 489454 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH:8]1[C:13]([C:14]#[N:15])=[C:12]([CH2:16]Br)[NH:11][C:10]2=[N:18][NH:19][CH:20]=[C:9]12.[CH3:21][N:22]1[CH2:28][CH2:27][CH2:26][NH:25][CH2:24][CH2:23]1>>[ClH:1].[ClH:1].[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH:8]1[C:13]([C:14]#[N:15])=[C:12]([CH2:16][N:25]2[CH2:26][CH2:27][CH2:28][N:22]([CH3:21])[CH2:23][CH2:24]2)[NH:11][C:10]2=[N:18][NH:19][CH:20]=[C:9]12

Participants

3

Reactant 2

HCID 2283491-MethylhomopiperazineHCID 178509439HCID 178509439, compound

Product 1

HCID 1784804544-(2-chlorophenyl)-6-[(4-methyl-1,4-diazepan-1-yl)methyl]-2,4-dihydro-1H-pyrazolo[3,4-b]pyridine-5-carbonitrile;dihydrochloride

Procedure

The title compound was prepared from 4-(2-chlorophenyl)-5-cyano-6-bromomethyl-4,7-dihydro-2H-pyrazolo[3,4-b]pyridine and N-methylhomopiperazine in the same manner as in Example 1076.

Sources & evidence

ORD record
ord-cae0f070c3b74c2f82e227cb46196ed7
Source dataset
uspto-grants-2005_12
Patent number
US06977262B2

Reaction notes

Loading…