1,4-Dioxane hydrochloride → HCID 178509396, compound

HRID 489458Notes

Reaction equation

HRID 489458 reaction equation
C(OC([N:8]1[CH2:12][CH2:11][CH:10]([C:13]2[NH:18][C:17]3=[N:19][NH:20][CH:21]=[C:16]3[CH:15]([C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=3[Cl:28])[C:14]=2[C:29]#[N:30])[CH2:9]1)=O)(C)(C)C.O1CCOCC1.Cl>>[Cl:28][C:23]1[CH:24]=[CH:25][CH:26]=[CH:27][C:22]=1[CH:15]1[C:14]([C:29]#[N:30])=[C:13]([CH:10]2[CH2:11][CH2:12][NH:8][CH2:9]2)[NH:18][C:17]2=[N:19][NH:20][CH:21]=[C:16]12

Participants

3

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 178451762HCID 178451762, compound

Product 1

HCID 178509396HCID 178509396, compoundYield 85.2%

Procedure

6-(1-tert-Butoxycarbonylpyrrolidin-3-yl)-4-(2-chlorophenyl)-5-cyano-4,7-dihydro-2H-pyrazolo[3,4-b]pyridine (706 mg) was added to 4N-HCl dioxane solution (5 mL) at room temperature and the mixture was stirred for 2 hours. The solvent was evaporated under reduced pressure and the residue was washed by ethanol-ethyl acetate, and the precipitated crystals were collected by filtration to give the title compound (460 mg) as colorless crystals.

Workup

  1. customThe solvent was evaporated under reduced pressure
  2. washthe residue was washed by ethanol-ethyl acetate
  3. filtrationthe precipitated crystals were collected by filtration

Sources & evidence

ORD record
ord-878f49860c4c48eaad4cf6a4e58f4a5c
Source dataset
uspto-grants-2005_12
Patent number
US06977262B2

Reaction notes

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