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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 48947Generated: October 28, 2026

1,4-Dimethyl-1H-imidazole-5-carboxylic acid → 3-Cyclopropyl-5-(3,5-dimethyl-3H-imidazol-4-yl)-[1,2,4]oxadiazole

https://huagongshe.com/reaction/48947

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1,4-Dimethyl-1H-imidazole-5-carboxylic acidHCID 12685485—
ReactantHCID 178513214HCID 178513214—
Product3-Cyclopropyl-5-(3,5-dimethyl-3H-imidazol-4-yl)-[1,2,4]oxadiazoleHCID 22271741—

Reaction Steps

The title compound, off-white solid, m.p. 88° C. and MS: m/e=204.3 (M+), was prepared from 3,5-dimethyl-3H-imidazole-4-carboxylic acid and N-hydroxy-cyclopropane-carboxamidine in accordance with the general procedure of example 12a.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06706707B2
Source datasetuspto-grants-2004_03
ORD IDord-4ea3b82f043b4248ad0f17e237fd8baf
Source noteuspto-grants-2004_03