1,2-Dichloroethane → HCID 10187421, compound

Participants

Reaction Steps

The title compound was prepared according to the procedure described in Example 1, Step (f) using (2R)-2-amino-3-(4-chlorophenyl)-1-(4-{2-[(methylsulfonyl)-amino]phenyl}piperidyl)propan-1-one (Example 1, Step g) (210 mg, 0.48 mmol), N-methyl S-proline (Hachem Company) (68 mg, 0.53 mmol), HOAT (Aldrich) (65 mg, 0.48 mmol), EDC (Aldrich) (184 mg, 0.96 mmol) and DIEA (Aldrich) (84 μL, 0.48 mmol). Purification by reverse phase preparative HPLC (Phenomenex; 5 μm 250×21.2 mm, 5% to 95% CH3CN (0.1% TFA) in H2O (0.1% TFA) over 30 min, then 100% CH3CN (0.1% TFA) for 2 min]provided the title compound as a colorless oil (120 mg). MS (ESI, pos. ion) m/z: 547 (M+1). Calc'd for C27H35ClN4O4S: 546.21.

Provenance & Evidence