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HRID489651

反应详情

EQUATION

反应方程式

HRID 489651 的结构方程式

REACTANTS

反应物

5
结构：ClCCCl
HCID11

1,2-Dichloroethane

C2H4Cl2

结构：CCN(C(C)C)C(C)C
HCID81531

Diisopropylethylamine

C8H19N

结构：On1nnc2cccnc21
HCID181649

3H-1,2,3-Triazolo[4,5-b]pyridine, 3-hydroxy-

C5H4N4O

结构：CC(C)(C)OC(=O)N[C@@H]1CC[C@H](C(=O)O)C1
HCID1512529

(1S,3R)-3-[[(1,1-Dimethylethoxy)carbonyl]amino]cyclopentanecarboxylic acid

C11H19NO4

结构：CS(=O)(=O)Nc1ccccc1C1CCN(C(=O)[C@H](N)Cc2ccc(Cl)cc2)CC1
HCID69140350

未命名化合物

PRODUCTS

生成物

1
结构：CC(C)(C)OC(=O)N[C@H]1CC[C@@H](C(=O)N[C@H](Cc2ccc(Cl)cc2)C(=O)N2CCC(c3ccccc3NS(C)(=O)=O)CC2)C1
HCID69151551

未命名化合物

收率 65%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CN(C)C=O
溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

PROCEDURE

实验过程

The title compound was prepared according to the procedure described in Example 1, Step (f) using (2R)-2-amino-3-(4-chlorophenyl)-1-(4-{2-[(methylsulfonyl)-amino]phenyl}piperidyl)propan-1-one (Example 1, Step g) (471 mg, 1.0 mmol), DIEA (Aldrich) (0.20 mL, 1.0 mmol), (+)-(1R, 3S)—N-Boc-aminocyclopentane-3-carboxylic acid (PepTech Corporation) (344 mg, 1.5 mmol), HOAT (Aldrich) (232 mg, 1.70 mmol) and EDC (Aldrich) (544, 2.84 mmol) in DMF (10 mL). Purification by silica gel chromatography (100% EtOAc) provided the title compound as a white foam (421 mg). MS (ESI, pos. ion) m/z: 647 (M+1); MS (ESI, neg ion) m/z: 645 (M−1). Calc'd for C32H43ClN4O6S: 647.23.

WORKUP

后处理

  1. customThe title compound was prepared
  2. customPurification by silica gel chromatography (100% EtOAc)