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HRID489654

反应详情

EQUATION

反应方程式

HRID 489654 的结构方程式

REACTANTS

反应物

2
结构：O=C(O)C(F)(F)F
HCID6422

未命名化合物

结构：CC(C)(C)OC(=O)N[C@@H]1CC[C@H](C(=O)N[C@H](Cc2ccc(Cl)cc2)C(=O)N2CCC(c3ccccc3NS(C)(=O)=O)CC2)C1
HCID23587435

未命名化合物

PRODUCTS

生成物

1
结构：CS(=O)(=O)Nc1ccccc1C1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2CC[C@@H](N)C2)CC1
HCID10119930

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：ClCCl
溶剂HCID6344

Dichloromethane

CH2Cl2

PROCEDURE

实验过程

The title compound was prepared according to the procedure described in Example 3 Step (b) from N-[(1R)-1-[(4-chlorophenyl)methyl]-2-(4-{2-[(methylsulfonyl)-amino]phenyl}-piperidyl)-2-oxoethyl]{(1S,3R)-3-[(tert-butoxy)carbonylamino]-cyclopentyl}-carboxamide (Step a) (323 mg, 0.5 mmol) and a 50% soln of TFA in CH2Cl2 (20 mL). Purification by preparative HPLC [Phenomenex; 5 μm 250×21.2 mm, 5% to 95% CH3CN (0.1% TFA) in H2O (0.1% TFA) over 30 min, then 100% CH3CN (0.1% TFA) for 2 min]provided the title compound (TFA salt) as a white foam (113 mg). MS (ESI, pos. ion) m/z: 547 (M+1); (ESI, neg. ion) m/z: 545 (M-1). Calc'd for C27H35ClN4O4S: 546.21.

WORKUP

后处理

  1. customThe title compound was prepared
  2. customPurification by preparative HPLC [Phenomenex