反应详情

The title compound was prepared according to the procedure described in Example 1, Step (f) using (2R)-2-amino-3-(4-chlorophenyl)-1-(4-(2-[(methylsulfonyl)-amino]phenyl)piperidyl)propan-1-one (Example 1, Step g) (118 mg, 0.25 mmol), DIEA (Aldrich) (0.05 mL, 0.25 mmol), DL-pyroglutamic acid (Aldrich) (344 mg, 0.5 mmol), HOAT (Aldrich) (68.2 mg, 0.5 mmol) and EDC (Aldrich) (95.8 mg, 0.5 mmol) in DMF (3 mL). Purification by silica gel chromatography (100% EtOAc) provided the title compound as a colorless film (82 mg). MS (ESI, pos. ion) m/z: 547 (M+1); (ESI, neg. ion) in/z: 545 (M−1). Calc'd for C26H31ClN4O5S: 546.17.

1. customThe title compound was prepared
2. customPurification by silica gel chromatography (100% EtOAc)