反应详情

The title compound was prepared according to the procedure described in Example 1, Step (f) using (2R)-2-amino-3-(4-chlorophenyl)-1-(4-{2-[(methylsulfonyl)-amino]phenyl}piperidyl)propan-1-one (Example 1, Step g) (471 mg, 1.0 mmol), DIEA (Aldrich) (0.20 mL, 1.0 mmol), N-Boc-4-piperidineacetic acid (AstaTech, Inc.) (365 mg, 1.5 mmol), HOAT (Aldrich) (232 mg, 1.70 mmol) and EDC (Aldrich) (544 mg, 2.84 mmol) in DMF (10 mL). Purification by silica gel chromatography (100% EtOAc) provided the title compound as a white foam (441 mg). MS (ESI, pos. ion) m/z: 661 (M+1); (ESI, neg. ion) m/z: 590 (M−1). Calc'd for C33H45ClN4O6S: 661.25.

1. customThe title compound was prepared
2. customPurification by silica gel chromatography (100% EtOAc)