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HRID489661

反应详情

EQUATION

反应方程式

HRID 489661 的结构方程式

REACTANTS

反应物

2
结构：O=C(O)C(F)(F)F
HCID6422

未命名化合物

结构：CC(C)(C)OC(=O)N1CCC[C@H]1C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCC(c2ccccc2NS(C)(=O)=O)CC1
HCID23587441

未命名化合物

PRODUCTS

生成物

1
结构：CS(=O)(=O)Nc1ccccc1C1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H]2CCCN2)CC1
HCID10208819

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：ClCCl
溶剂HCID6344

Dichloromethane

CH2Cl2

PROCEDURE

实验过程

The title compound was prepared according to the procedure described in Example 3, Step (b) from tert-butyl 2-{N-[(1R)-1-[(4-chlorophenyl)methyl]-2-(4-(2-[(methylsulfonyl)-amino]-phenyl)-piperidyl)-2-oxoethyl]carbamoyl}(2S)pyrrolidinecarboxylate (Step a) (315 mg, 0.5 mmol) and 50% TFA in CH2Cl2 (20 mL). Purification by preparative reverse phase HPLC [Phenomenex; 5 μm 250×21.2 mm, 5% to 95% CH3CN (0.1% TFA) in H2O (0.1% TFA) over 30 min, then 100% CH3CN (0.1% TFA) for 2 min] provided the title compound (TFA salt) as a white foam (101 mg). MS (ESI, pos. ion) m/z: 533 (M+1); (ESI, neg. ion) m/z: 531 (M−1). Calc'd for C26H33ClN4O4S: 532.19. Anal. Calcd for C26H33ClN4O4S.1.2C2HF3O2: C, 50.92; H, 5.15; N, 8.36. Found: C, 50.82; H, 5.32; N, 8.38.

WORKUP

后处理

  1. customThe title compound was prepared
  2. customPurification by preparative reverse phase HPLC [Phenomenex