Hydrochloric Acid → HCID 9809706, compound

Participants

Reaction Steps

To a 250 mL round-bottomed flask equipped with stirring was added tert-butyl 3-{N-[(1R)-1-[(4-chlorophenyl)-methyl]-2-(4-{2-[(cyclopropylmethyl)-(methylsulfonyl)-amino]phenyl}piperidyl)-2-oxoethyl]carbamoyl}(3S)-1,2,3,4-tetrahydroisoquinoline-2-carboxylate (Step c) (1.9 g, 2.5 mmol) followed by a saturated soln of HCl in EtOAc (150 mL). The mixture was stirred at RT for 1 h then concentrated in vacuo to 75 mL, providing a white precipitate. The precipitate was collected by filtration and dried in vacuo to provide the HCl salt as a white solid (0.93 g). MS (ESI, pos. ion) m/z: 649 (M+1). Calc'd for C35H41ClN4O4S: 648.25.

Provenance & Evidence