1,2-Dichloroethane → HCID 23587433, compound

Participants

Reaction Steps

The title compound was prepared according to the procedure described in Example 1 (Step f) using 1-(2-(4-piperidyl)phenyl)ethan-1-ol hydrochloride (Step c) (0.72 g, 3.0 mmol), DIEA (0.54 mL, 3.0 mmol), Boc-p-Cl-D-PheOH (PepTech Corporation) (1.36 g, 4.5 mmol), HOAT (Aldrich) (0.615 g, 4.5 mmol) and EDC (Aldrich) (0.864 g, 4.5 mmol) in DMF (5 mL). Purification by silica gel chromatography (100% EtOAc) provided the title compound as a white foam (1.09 g). MS (EST, pos. ion) m/z. 487 (M+1); MS (ESI, neg. ion) m/z: 485 (M−1). Calc'd for C27H35ClN2O4: 486.23.

Provenance & Evidence