Trifluoroacetic acid → HCID 10117666, compound

Participants

Reaction Steps

The title compound was prepared according to the procedure described in Example 3 (Step b) from tert-butyl (3S)-3-(N-((1R)-2-[4-(2-methoxyphenyl)piperidyl]-2-oxo-1-benzylethyl]carbamoyl)-1,2,3,4-tetrahydro-isoquinoline-2-carboxylate (Step b) (1.4 g, 2.34 mmol) and 50% TFA in CH2Cl2 (80 mL). Purification by reverse phase preparative HPLC [Phenomenex; 5 μm 250×21.2 mm, 5% to 95% CH3CN (0.1% TFA) in H2O (0.1% TFA) over 30 min, then 10U % CH3CN (0.1% TFA) for 2 min] provided the title compound (TFA salt) as a white foam (0.5 g). MS (ESI, pos. ion) m/z: 498 (M+1). Calc'd for C31H35N3O3: 497.27.

Provenance & Evidence