1,2-Dichloroethane → HCID 69151723, compound

Participants

Reaction Steps

The title compound was prepared according to the procedure described in Example 1, (Step f) from 2-(2-[(methylsulfonyl)(2-(4-piperidyl)phenyl)amino]ethyl) isoindoline-1,3-dione hydrochloride (Step b) (1.28 g, 2.8 mmol), DIEA (0.54 mL, 3.0 mmol), Boc-p-Cl-D-PheOH (PepTech Corporation) (1.36 g, 4.5 mmol), HOAT (Aldrich) (0.615 g, 4.5 mmol) and EDC (Aldrich) (0.864 g, 4.5 mmol) in DMF (15 mL). Purification by silica gel chromatography (1:1 hexane:EtOAc) provided the title compound as a white foam (1.83 g %). MS (ESI, pos. ion) m/z: 709 (M+1); MS (ESI, neg. ion) m/z: 707 (M−1). Calc'd for C36H41ClN4O7S: 708.24.

Provenance & Evidence