Hydrochloric Acid → HCID 60054561, compound

Participants

Reaction Steps

The title compound was prepared according to the procedure described in Example 10 (Step c) from tert-butyl (3S)-3-[N-((1R)-1-[(4-chlorophenyl)methyl]-2-(4-[2-(3-methyl-2-oxo(4-imidazolinyl))phenyl]piperidyl)-2-oxoethyl)carbamoyl]-1,2,3,4-tetrahydroisoquinoline-2-carboxylate (Step c) (0.12 g, 0.17 mmol) and satd anhydrous HCl in EtOAc (50 mL). Recrystallization from 1:10 CH2Cl2:Kt2O provided the title compound (HCl salt) as a white solid (0.06 g). MP 178° C. (decomposed). MS (ESI, pos. ion) m/z: 598 (M+1). Calc'd for C34H36ClN5O3: 597.25. Anal. Calcd for C34H35ClN5O3.HCl.1.25H2O—C, 62.15; H, 6.06; N, 10.66; Cl, 10.79. Found: C, 62.20; H, 6.02; N, 10.68; Cl, 10.65.

Provenance & Evidence